福利姬

2004.08-2009.09     纽约大学，化学，博士，导师: Ned Seeman院士

1999.09-2004.07     中国科学技术大学，应用化学，学士，导师: 钱逸泰院士

2022.01-                  福利姬 -福利姬 /转化医学院，研究员

2015.06-2021.12     复旦大学-生物医学研究院，研究员

2009.11-2015.05     耶鲁大学，分子生物学，博士后，导师: Ronald Breaker院士

擅长核酸编辑和组装，致力于开拓DNA在纳米材料、生物传感、临床诊断等方面的基础和应用研究，开展的方向包括：

1. 对靶点或标志物明确的重大恶性肿瘤和慢性疾病，开发可用于体液诊断的便捷核酶探针（试剂盒）；对于标志物未知的重大恶性肿瘤和慢性疾病（主要是三阴性乳腺癌），以核酶探针库为抓手，通过临床样本间的对冲抵消，筛选鉴定疾病相关的标志物和对应的检测探针，揭示疾病的分子机制并明确药物可作用的靶点；

2. 开发新型3D框架核酸的设计和组装方案，在保持组装体近原子分辨率的前提下，将自组装的尺度在3D空间从纳米推向微米和亚毫米级，以满足其作为介质在材料科学中的更多应用需求；同时开发活细胞生产制备框架核酸的生物技术，降低制备成本，为框架核酸的临床研究提供支持；

3. 利用试管内进化的高效筛选策略分离获得重大疾病相关的核酸酶（DNAzyme和Ribozyme），将其与框架核酸融合，编辑组装“环境响应型智能纳米药物载体”，用于重大疾病的靶向精确递药。

9. 国自然基金委青年科学基金项目（A类）[原国家杰出青年科学基金项目]

     项目编号：22525404，  2026-2030  主持  400万

8. 国自然基金委创新研究群体 “肿瘤免疫治疗新策略”

     项目编号：82121002，  2022-2026  骨干 主持  200万

7. 科技部重点研发计划 “微纳生物机器人的定向合成和诊疗应用”（课题一）

     课题编号：2020YFA0908901，  2020-2025  主持  604万

6. 国自然基金委重大研究计划 “肿瘤演进与诊疗的分子功能可视化研究”（培育项目）

     项目编号：91859104，  2019-2021  主持  60万

5. 江苏贝格尔生物医药有限公司 横向合作课题“外泌体捕捉与生物标记物检测开发”

     2019-2020  主持  30万

4. 国自然国际（地区）合作与交流重大项目“靶向治疗类风湿性关节炎的核酸纳米抗体研究”

     项目编号：81861138004，  2018-2020  共同主持  总经费300万，个人承担150万

3. 国自然面上项目 “DNA纳米骨架的组装及其在生物和材料学中的应用”

     项目编号：21673050，  2017-2020  主持  已结题  68万

2. 科技部国家重点研发计划“重大慢性非传染性疾病防控研究”

     项目编号：2016YFC1306400， 2016-2020  子课题负责人  45.4万

1. 主持国家级青年人才项目   2015-2018  主持  300万

代表性文章（独立PI期间）

34. Chunhai Fan*; Hongzhou Gu. “DNA Nanotechnology for Optoelectronics and Biomedicine.” JACS Au 2025, 5, 5236.

33. Xinyue Tang^¥; Tingting Zhai^¥*; Tiancheng Li; Yu Jin; Dantong Lei; Cheng Zhu; Luyao Qu; Yingfu Li; Yudong Wang; Hongzhou Gu*; Bing Fang*. “Dimensional control of DNA nanostructures enhances cellular uptake and guides tissue-regenerative responses.” Journal of Nanobiotechnology 2025, 23: 615.

32. Chenghui Qian^¥; Si Chen^¥; Liman Chen^¥; Chenyang Zhang; Lingyi Yang; Qiaowei Li; Binbin Kang; Xiaohong Chen; Peter Mei; Hongzhou Gu*; Yan Liu*; Yuehua Liu*. “Tetrahedral DNA Nanostructure-Modified Nanocoating for Improved Bioaffinity and Osseointegration of Titanium.” Small 2025, 2412747.

31. Lichuan Guo^¥; Shu Zhang^¥; Xinyu Du*; Mo Zhou*; Hongzhou Gu*. “Fusing Allosteric Ribozymes with CRISPR-Cas12a for Efficient Diagnostics of Small Molecular Targets.” Small Methods 2024, 2401236.

30. Qinqin Hu^¥; Zongxuan Tong^¥; Ayimukedisi Yalikong^¥; Li-Ping Ge^¥; Qiang Shi; Xinyu Du; Pu Wang; Xi-Yu Liu; Wuqiang Zhan; Xia Gao; Di Sun; Tong Fu; Dan Ye; Chunhai Fan; Jie Liu; Yun-Shi Zhong*; Yi-Zhou Jiang*; Hongzhou Gu*. “DNAzyme-Based Faithful Probing and Pulldown to Identify Candidate Biomarkers of Low Abundance.” Nature Chemistry 2024, 16, 122-131.

29. Mo Zhou^¥; Tianbin Xu^¥; Kai Xia; Haiqing Gao; Wei Li; Tingting Zhai; Hongzhou Gu*. “Small DNAs That Specifically and Tightly Bind Transition Metal Ions.” Journal of the American Chemical Society 2023, 145, 16, 8776-8780.

28. Xiao Chu; Xinyu Du; Longhua Yang; Ziyi Wang; Yi Zhang; Xiaonan Wang; Lijun Dai; Jiangnan Zhang; Jie Liu; Nan Zhang*; Yongxing Zhao*; Hongzhou Gu*. “Targeting Tumor Necrosis Factor Receptor 1 with Selected Aptamers for Anti-Inflammatory Activity.” ACS Applied Materials & Interfaces 2023, 15, 11599-11608.

27. Qiao Zhang^¥; Kai Xia^¥; Meng Jiang^¥; Qingting Li; Weigang Chen; Mingzhe Han; Wei Li; Rongqin Ke; Fei Wang; Yongxing Zhao; Yuehua Liu; Chunhai Fan; Hongzhou Gu*. “Catalytic DNA-Assisted Mass Production of Arbitrary Single-Stranded DNA.” Angewandte Chemie International Edition 2023, e202212011.

26. Jin Liu^¥; Liman Chen^¥; Tingting Zhai; Wei Li; Yuehua Liu; Hongzhou Gu*. “Programmable Assembly of Amphiphilic DNA through Controlled Cholesterol Stacking.” Journal of the American Chemical Society 2022, 144, 36, 16598-16603.

25. Yang Yang^¥; Zhenyong Wu^¥; Laurie Wang; Kaifeng Zhou; Kai Xia; Qiancheng Xiong; Longfei Liu; Zhao Zhang; Edwin R Chapman; Yong  Xiong; Thomas J Melia; Erdem Karatekin; Hongzhou Gu*; Chenxiang Lin*. “Sorting liposomes of distinct sizes by DNA-brick assisted centrifugation.” Nature Chemistry 2021, 13, 335-342.

24. Youli Jia^¥; Liman Chen^¥; Jin Liu; Wei Li; Hongzhou Gu*. “DNA Catalyzed Efficient Production of Single-stranded DNA Nanostructures.” Chem 2021, 7, 4, 959-981.

23. Qingting Li; Zongxuan Tong; Yichun Cao; Hongzhou Gu*. “DNAs catalyzing DNA nanoconstruction.” Chem 2021, 7, 10, 2556-2568.

22. Canyu Zhang; Qingting Li; Tianbin Xu; Wei Li; Yungang He; Hongzhou Gu*. “New DNA-hydrolyzing DNAs isolated from an ssDNA library carrying a terminal hybridization stem.” Nucleic Acids Research 2021, 49, 11, 6364-6374.

21. Xinyu Du^¥; Xiaoqin Cheng^¥; Wei Li; Zhilei Ge; Chunjiu Zhong; Chunhai Fan; Hongzhou Gu*. "Engineering allosteric ribozymes to detect thiamine pyrophosphate in whole blood.” Analytical Chemistry 2021, 93, 9, 4277-4284.

20. Tianbin Xu^¥; Canyu Zhang^¥; Kai Xia; Wei Li; Yichun Cao; Hongzhou Gu*. “Small DNAs that bind nickel(II) specifically and tightly.” Analytical Chemistry 2021, 93, 45, 14912-14917.

19. Qingting Li; Shu Zhang; Wei Li; Zhilei Ge; Chunhai Fan; Hongzhou Gu*. “Programming CircLigase catalysis for DNA rings and topologies.” Analytical Chemistry 2021, 93, 3, 1801-1810.

18. Jin Liu; Hongzhou Gu*. “Biotechnological production of ssDNA with DNA-hydrolyzing deoxyribozymes.” STAR Protocols 2021, 2, 2, 100531.

17. Huiyan Li; Fangfei Yin; Xinyi Li; Wannan Jia; Jia Ding; Li Zhang; Zhonghua Wang; Qinqin Hu; Jieliang Zuo; Huliang Jia; Lihua Wang; Chunhai Fan*; Hongzhou Gu*; Jian Wu*. “Novel aptasensor-based assay of sonic hedgehog ligand for detection of portal vein invasion of hepatocellular carcinoma.” Biosensors and Bioelectronics 2021, 174, 112738.

16. Dong-Jie Tang^¥; Xinyu Du^¥; Qiang Shi^¥; Jian-Ling Zhang^¥; Yuan-Ping He; Yan-Miao Chen; Zhenhua Ming; Dan Wang; Wan-Ying Zhong; Yu-Wei Liang; Jin-Yang Liu; Jian-Ming Huang; Yun-Shi Zhong; Hongzhou Gu*; Ji-Liang Tang*. “A SAM-I riboswitch with the ability to  sense and respond to uncharged initiator tRNA.” Nature Communications 2020, 11, 2794, 1-11.

15. Kai Xia; Jianlei Shen; Qian Li; Chunhai Fan*; Hongzhou Gu*. “Near-Atomic Fabrication with Nucleic Acids.” ACS Nano 2020, 14, 1319-1337.

14. Ziyi Wang; Xiao Chu; Na Li; Lingling Fu; Hongzhou Gu*; Nan Zhang*. “Engineered DNA nanodrugs alleviate inflammation in inflammatory arthritis.” International Journal of Pharmaceutics 2020, 577, 119047.

13. Zongxuan Tong; Qinqin Hu; Hongzhou Gu*. “Deoxyribozymes: selection, biosensing and outlook.” Chemical Journal of Chinese Universities 2020, 41(11), 2345-2355.

12. Qinqin Hu^¥; Hua Li^¥; Lihua Wang; Hongzhou Gu*; Chunhai Fan*. “DNA Nanotechnology Enabled Drug Delivery systems.” Chemical  Reviews 2019, 119, 6459-6506.

11. Hua Li; Jin Liu; Hongzhou Gu*. “Targeting Nucleolin to Obstruct Vasculature Feeding with An Intelligent DNA Nanorobot.” Journal of Cellular and Molecular Medicine 2019, 23, 2248-2250.

10. Xinyu Du^¥; Xin Zhong^¥; Wei Li; Hua Li*; Hongzhou Gu*. “Retraining and Optimizing DNA-Hydrolyzing Deoxyribozymes for Robust Single- and Multiple-Turnover Activities.” ACS Catalysis 2018, 8, 5996-6005.

9. Zhilei Ge^¥; Hongzhou Gu^¥; Qian Li; Chunhai Fan*. “Concept and Development of Framework Nucleic Acids.” Journal of the American Chemical Society 2018, 140, 51, 17808-17819.

8. Qinqin Hu; Sheng Wang; Lihua Wang; Hongzhou Gu*; Chunhai Fan*. “DNA Nanostructure-Based Systems for Intelligent Delivery of Therapeutic Oligonucleotides.” Advanced Healthcare Materials 2018, 7, 1701153.

7. Hongzhou Gu*. “Single-molecule Genotyping with Nanoscale DNA Shape IDs.” Science China Chemistry 2017, 60, 1111-1112.

代表性文章（博士-博后期间）

6. Hongzhou Gu; Kazuhiro Furukawa; Zasha Weinberg; Daniel F. Berenson; Ronald R. Breaker. “Small, Highly-active DNAs that Hydrolyze DNA.” Journal of the American Chemical Society 2013, 135, 9121-9129.

5. Hongzhou Gu; Ronald R. Breaker. “Production of Single-stranded DNAs by Self-cleavage of Rolling-circle Amplification Products.” BioTechniques 2013, 54, 337-343.

4. Hongzhou Gu; Kazuhiro Furukawa; Ronald R. Breaker. “Engineered Allosteric Ribozymes that Sense the Bacterial Second Messenger c-di-GMP.” Analytical Chemistry 2012, 84, 4935-4941.

3. Hongzhou Gu; Jie Chao; Shou-Jun Xiao; Nadrian C. Seeman. “A Proximity-Based Programmable DNA Nanoscale Assembly Line.” Nature 2010, 465, 202-205.

2. Hongzhou Gu; Wei Yang; Nadrian C. Seeman. “DNA Scissors Device Used to Measure MutS Binding to DNA Mis-Pairs.” Journal of the American Chemical Society 2010, 132, 4352-4357.

1. Hongzhou Gu; Jie Chao; Shou-Jun Xiao; Nadrian C. Seeman. “Dynamic Patterning Programmed by DNA Tiles Captured on a DNA Origami Substrate.” Nature Nanotechnology 2009, 4, 245-248.

已建成“核酸生物医学工程与技术”平台，并形成了包括1名助理研究员、3名博士后、12名博士生、3名科研助理的研究团队，成员多次获得“上海市超级博士后激励计划”、“博士生国家奖学金”、“上海市优秀毕业生”等奖励和称号。

主要专利

12. DNAzyme and use thereof

      专利号：PCT/CN2022/085696

       发明人：顾宏周、张俏、夏凯、李富友

11. IV类脱氧核酶突变体及其制备方法与应用

      专利号：202011118638.7

      发明人：顾宏周、张灿钰、李青婷

10. III类脱氧核酶突变体及其制备方法与应用

       专利号：202011120065.1

       发明人：顾宏周、张灿钰、李青婷

9.  一种利用单链DNA纳米结构辅助分选脂质体的方法

       专利号：202010773498.0

       发明人：顾宏周、陈黎曼

8.  差异筛选特异感应三阴性乳腺癌的脱氧核酶探针

       专利号：202110364792.0

       发明人：顾宏周、胡沁沁

7.  一种富集、鉴定待测病样中分子标志物的方法

       专利号：202110361337.5

       发明人：顾宏周、胡沁沁

6.  能快速水解DNA的II类脱氧核酶突变体

       专利号：201910989374.3

       发明人：顾宏周、张俏

5.  一种长单链DNA的制备方法

       专利号：201910989379.6

       发明人：顾宏周、张俏

4.  提高单链DNA连接效率的方法

       专利号：ZL202011011345.9

       发明人：顾宏周、李青婷

3.  一种脱氧核酶切割方法

       专利号：ZL201810131087.4

        发明人：顾宏周

2.  能快速水解DNA的脱氧核酶突变体

       专利号：ZL201810131100.6

       发明人：顾宏周

1.  一种检测硫胺素焦磷酸的RNA传感器及其应用

       专利号：ZL201810077122.9

       发明人：顾宏周、杜鑫雨、钟春玖、程小芹

JACS Au 客座编辑

 个人奖项

    2014年获评国家级青年人才

    2017年上海市高层次人才项目

    2022年上海市优秀学术带头人

    2025年国家杰出青年（青A）项目

长期招收博士生及博士后！